The building is now a local history museum. Lee, who fired the first shot of the Civil War upon Fort Sumter. The first home of Pulitzer Prize-winning playwright Tennessee Williams, built in 1875, has been preserved and today serves as a Mississippi welcome center.Ĭolumbus contains three National Register Districts with approximately 650 properties, including the Blewett-Harrison-Lee Home, the 1847 Italianate home of General Stephen D. The town was first settled in 1817.Ĭolumbus is home to the first state-supported college for women in the nation, the Columbus Female Institute, founded in 1847, now the Mississippi University for Women. Historic Preservation Contacts and ResourcesĬolumbus, Mississippi (population 26,000) is located on the Tombigbee River in east central Mississippi.